Title:Regulating Inflammation Associated Ferroptosis - A Treatment Strategy for Parkinson Disease
Volume: 28
Issue: 33
关键词:
铁死亡、帕金森病、铁积累、炎症、神经变性、药物。
摘要: Ferroptosis plays a critical regulatory role as a new kind of cell death, initiating
and developing an array of disorders like neurological diseases, acute injury of kidney,
tumors, and ischemia, etc. Although selective deposition of iron is one of the pathogenic
reasons for PD, it’s underlying mechanism is still unknown. In this review, the role
of neuroinflammation in Parkinson’s disease (PD) leading to neurodegeneration has been
discussed in detail. The accumulation of brain iron has been found in many chronic neurological
disorders, including PD. We have also discussed the unique features of ferroptosis
, and it links in aggravating the pathology of PD. Further, the concept of targeting ferroptosis
for PD pathology and inducers and inhibitors, pharmacological drugs and clinical
trials for PD candidates in phase IV stage in completed status are detailed in the respective
sections.
