Title:Regulating Inflammation Associated Ferroptosis - A Treatment Strategy for Parkinson Disease
Volume: 28
Issue: 33
Author(s): Marthandam Asokan Shibu, Mahalakshmi Bharath and Bharath Kumar Velmurugan*
Affiliation:
- Department of Medical Laboratory Science and Biotechnology, Asia University, Taichung,Taiwan
Keywords:
Ferroptosis, Parkinson's disease, iron accumulation, inflammation, neurodegeneration, drugs.
Abstract: Ferroptosis plays a critical regulatory role as a new kind of cell death, initiating
and developing an array of disorders like neurological diseases, acute injury of kidney,
tumors, and ischemia, etc. Although selective deposition of iron is one of the pathogenic
reasons for PD, it’s underlying mechanism is still unknown. In this review, the role
of neuroinflammation in Parkinson’s disease (PD) leading to neurodegeneration has been
discussed in detail. The accumulation of brain iron has been found in many chronic neurological
disorders, including PD. We have also discussed the unique features of ferroptosis
, and it links in aggravating the pathology of PD. Further, the concept of targeting ferroptosis
for PD pathology and inducers and inhibitors, pharmacological drugs and clinical
trials for PD candidates in phase IV stage in completed status are detailed in the respective
sections.
