Title:Factors Determining the Metal Ion Binding Ability and Selectivity of Hydroxamate-Based Compounds
Volume: 28
Issue: 35
关键词:
异羟肟酸作为配体、基于异羟肟酸盐的铁载体、形态模型、金属配合物稳定性、金属结合效率、金属离子选择性。
摘要:
There has been a long tradition for a broad spectrum of applications of both natural
and synthetic hydroxamic acids and derivatives. Even nowadays, a huge number of
newly designed representatives (from different monohydroxamate-based compounds to
siderophore conjugates) are used to develop potential drug candidates with desired activities.
Since these compounds are effective metal-chelating agents, their biological roles
and actions as well as their various applications, e.g., in the medicinal practice, are all in
direct correlation with their metal complexation. Consequently, the knowledge of the stoichiometry
and binding modes of metal complexes with hydroxamic acid-based ligands,
their thermodynamic parameters, and speciation profiles in solution are crucial for scientists
working in any of the above-mentioned fields.
This review, in addition to presenting a few factors, which might affect the metal-binding
capabilities of these organic ligands, displays and summarizes the different parameters
typically used to give the stoichiometry, composition, and stability of the species formed
in a solution equilibrium system in measurable concentration. Discussion of the possibilities
for quantitative comparison of metal-binding effectivity and selectivity of various hydroxamic
acids with each other by using solution equilibrium data is also the focus of
this publication.
