Title:Recent Advances in Neuromyelitis Optica Spectrum Disorder: Pathogenesis,
Mechanisms and Potential Treatments
Volume: 28
Issue: 4
Author(s): Yi Du, Kaijun Li, Wei Liu, Ruitong Song, Meifeng Luo, Jianfeng He, Xiaoyu Xu*Xiaosheng Qu*
Affiliation:
- Doheny Eye Institute, Department of Ophthalmology, University of California, Los Angeles, CA 90033,United States
- National Engineering Laboratory of Southwest Endangered Medicinal Resources Development, Guangxi Botanical Garden of Medicinal Plants, 530023, Nanning,China
Keywords:
Devic’s disease, AQP4, autoimmunity, pathogenesis, therapy, NMOSD
Abstract: Neuromyelitis optica spectrum disorder (NMOSD) is an acute or subacute demyelinating disease
that affects mainly the optic nerve and spinal cord. A major proportion of NMOSD cases have a relationship
with autoimmunity to aquaporin 4 (AQP4) found on the central nervous system. NMOSD can occur repeatedly,
causing symptoms such as decreased vision and weakness of limbs. The main goal of the current therapy is to
relieve acute symptoms and prevent recurrence of the disease. Without timely and appropriate treatment, the recurrence
and disability rates are high. In the present work, we review recent advances in the diagnosis and treatment
of patients with NMOSD, as well as the pathogenesis and mechanisms of AQP4-IgG-seropositive
NMOSD.
