Title:ADAMTS9-AS2: A Functional Long Non-coding RNA in Tumorigenesis
Volume: 27
Issue: 23
Author(s): Wen Xu, Bei Wang , Yuxuan Cai, Jinlan Chen, Xing Lv , Chong Guo and Chengfu Yuan*
Affiliation:
- College of Medical Science, China Three Gorges University, Yichang 443002,China
Keywords:
Long non-coding RNA, ADAMTS9-AS2, malignant tumors, therapeutic targets, DNA methylation, mediating PI3K.
Abstract:
Background: Long non-coding RNAs (lncRNA) have been identified as novel molecular regulators
in cancers. LncRNA ADAMTS9-AS2 can mediate the occurrence and development of cancer through various
ways, such as regulating miRNAs, activating the classical signaling pathways in cancer, and so on, which have
been studied by many scholars. In this review, we summarize the molecular mechanisms of ADAMTS9-AS2 in
different human cancers.
Methods: Through a systematic search of PubMed, lncRNA ADAMTS9-AS2 mediated molecular mechanisms
in cancer are summarized inductively.
Results: ADAMTS9-AS2 aberrantly expression in different cancers is closely related to cancer proliferation, invasion,
migration, and inhibition of apoptosis. The involvement of ADAMTS9-AS2 in DNA methylation, mediating
PI3K / Akt / mTOR signaling pathways, and regulating miRNAs and proteins, shows its significant potential
as a therapeutic cancer target.
Conclusion: LncRNA ADAMTS9-AS2 can become a promising biomolecular marker and a therapeutic target
for human cancer.
