Title:The Effect of Natural Soluble Polysaccharides on the Type 2 Diabetes through Modulating Gut Microbiota: A Review
Volume: 28
Issue: 26
关键词:
2型糖尿病，多糖，肠道微生物群，代谢产物，加工过程，益生元
摘要: Diabetes strongly influences the patient’s quality of life. The incidence of type
2 diabetes (T2D) accounts for approximately 90% of diabetic patients. Natural
polysaccharides have been widely used for diabetes management. Changes in gut microbiota
can also be used for the prevention and treatment of diabetes. In this review, the effects
of different natural polysaccharides on gut microbiota, as well as the relationship between
diabetes and the gut microbiome are summarized. The intestine is the primary location
in which natural polysaccharides exert their biological activities and plays an important
role in maintaining healthy bodily functions. Polysaccharides change the composition
of the gut microbiota, which inhibits pathogen invasion and promotes beneficial bacterial
growth. In addition, the gut microbiota degrade polysaccharides and produce
metabolites to further modify the intestinal environment. Interestingly, the metabolites
(short chain fatty acids and other bioactive components) have been shown to improve gut
health, control glycemia, lower lipids, reduce insulin resistance, and alleviate inflammation.
Therefore, understanding the underlying mechanisms by which soluble
polysaccharides improve T2D through regulating the gut microbiota and provide a future
reference for the management of T2D and its associated complications.
