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Review Article

EGFR，PDGFR，FGFR和 VEGFRMediated 信号通路的天然来源抑制剂作为潜在的抗癌剂

卷 29, 期 2, 2022

发表于: 03 March, 2021

页: [212 - 234] 页: 23

弟呕挨: 10.2174/0929867328666210303101345

价格: $65

摘要

有丝分裂细胞周期进展的分子机制涉及非常严格限制的机器类型，这些机器由正负加速器（或调节剂）之间的精细平衡高度调节。这些调节剂包括几个检查点，这些检查点具有蛋白质作为酶及其激活伙伴的作用。这些检查点不断监测外部和内部环境，如生长信号，生长的有利条件，细胞大小，细胞的DNA完整性，因此通过维持细胞稳态和促进无差错DNA复制和细胞周期分裂来维持高度有序的细胞周期进展。为了通过有丝分裂细胞周期，细胞必须成功地通过细胞周期检查点。由于一些细胞周期蛋白的异常行为，细胞倾向于连续分裂，克服了细胞周期检查点的严格调节。这种异常可能导致不必要的细胞分裂，这种细胞周期事件的放松调节被认为是肿瘤发展背后的主要原因之一，从而导致癌症进展。因此，对癌症进展中分子机制的理解对于设计几种癌症治疗策略可能是有见地的。检查点的放松管制是由于TPK的酪氨酸残基通过PDGFR，EGFR，FGFR和VEGFR介导的信号通路的变化引起的。因此，PDGFR、EGFR、FGFR 和 VEGFR 介导的信号通路的抑制剂可能是潜在的抗癌药物。现有合成抗癌化疗药物的耐药性和毒性可能会缩短患者的寿命。长期以来，天然产品由于副作用和毒性最小或没有副作用和毒性，因此一直是治疗剂的重要替代来源。本研究试图促进天然抗癌药物的开发，重点是从植物来源分离的PDGFR，EGFR，FGFR和VEGFR抑制剂的最新结构信息。本综述中使用的数据是从互联网资源（即GOOGLE Web，GOOGLE SCHOLAR和PubMed Central）收集的。首先检查每份报告的引用，然后选择这些文章作为本研究的真实参考。最初选择了大约200篇期刊文章，其中约142篇最终被选中用于展示EGFR，PDGFR，FGFR和VEGFR介导的信号通路的天然来源抑制剂的研究，这可能有助于增强潜在的癌症治疗。

关键词: 癌症靶标，PDGFR，EGFR，FGFR，VEGFR，异常信号转导，天然抑制剂。

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