Title:Natural Sourced Inhibitors of EGFR, PDGFR, FGFR and VEGFRMediated
Signaling Pathways as Potential Anticancer Agents
Volume: 29
Issue: 2
Author(s): Sisir Nandi*, Rishita Dey, Asmita Samadder, Aaruni Saxena and Anil Kumar Saxena*
Affiliation:
- Global Institute of Pharmaceutical Education and Research, Kashipur-244713,India
- Global Institute of Pharmaceutical Education and Research, Kashipur-244713,India
Keywords:
Cancer targets, PDGFR, EGFR, FGFR, VEGFR, abnormal signal transduction, natural inhibitors.
Abstract: The molecular mechanisms of mitotic cell cycle progression involve very tightly
restricted types of machinery which are highly regulated by a fine balance between the
positive and negative accelerators (or regulators). These regulators include several checkpoints
that have proteins acting as enzymes and their activating partners. These checkpoints
incessantly monitor the external as well as internal environments such as growth
signals, favorable conditions for growth, cell size, DNA integrity of the cell and hence
function to maintain the highly ordered cell cycle progression by sustaining cell homeostasis
and promoting error-free DNA replication and cell cycle division. To progress
through the mitotic cell cycle, the cell has to successfully drive past the cell cycle checkpoints.
Due to the abnormal behavior of some cell cycle proteins, the cells tend to divide
continuously overcoming the tight regulation of cell cycle checkpoints. Such anomalies
may lead to unwanted cell division, and this deregulation of cell cycle events is considered
as one of the main reasons behind tumor development, and thus, cancer progression.
So the understanding of the molecular mechanisms in cancer progression might be insightful
for designing several cancer treatment strategies. The deregulation in the checkpoints
is caused due to the changes in the tyrosine residues of TPKs via PDGFR, EGFR,
FGFR, and VEGFR-mediated signaling pathways. Therefore, the inhibitors of PDGFR,
EGFR, FGFR, and VEGFR-mediated signaling pathways could be potential anticancer
agents. The resistance and toxicity in the existing synthetic anticancer chemotherapeutics
may decrease the life span of a patient. For long, natural products have played an essential
alternative source of therapeutic agents due to having least or no side effect and toxicity.
The present study is an attempt to promote natural anticancer drug development focusing
on the updated structural information of PDGFR, EGFR, FGFR, and VEGFR inhibitors
isolated from the plant sources. The data used in this review has been collected
from internet resources, viz. GOOGLE Web, GOOGLE SCHOLAR, and PubMed Central.
The citation of each report was first checked, after which the articles were selected
as an authentic reference for the present study. Around 200 journal articles were initially
selected, of which around 142 were finally chosen for presenting the study on the natural
sourced inhibitors of EGFR, PDGFR, FGFR, and VEGFR-mediated signaling pathways
which may help to enhance the potential cancer treatment.
