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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Research Article

An Efficient Synthesis of 3,4-dihydro-2(1H)-pyrimidinones from Aldehyde Bisulfite Adducts using Recyclable Wang Resin Supported Sulfonic Acid Catalyst

Author(s): Vinay Kumar K. Pavithran, Vinti S.P. Rao, Chikkanti Jaganmohan, Sandeep Mohanty , Jaydeep Kumar, Venkateswara Rao Battula, Kommineni Kalyani and Srinivasa Reddy Kallam *

Volume 19, Issue 6, 2022

Published on: 11 January, 2022

Page: [463 - 470] Pages: 8

DOI: 10.2174/1570178618666210225113723

Price: $65

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Abstract

An efficient one-pot multicomponent synthesis multicomponent synthesis of 3,4- dihydropyrimidin- 2(1H)-ones has been developed from aldehyde bisulfite adducts, ethyl acetoacetate and urea using recyclable polymer-supported sulfonic acid catalyst. This new method provides several advantages over the previous synthesis, including high product yields, commercially viable, minimal workup operations and sustainable chemical practices.

Keywords: 3, 4-dihydropyrimidin-2(1H)-ones, wang resin-supported sulfonic acid, recyclable catalyst, aldehyde bisulfite adduct, biginelli reaction, multicomponent synthesis.

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