Title:Emerging Molecular Functions of MicroRNA-9: Cancer Pathology and Therapeutic Implications
Volume: 21
Issue: 17
Author(s): Behnam Emamgolizadeh Gurt Tapeh , Bashir Mosayyebi, Behzad Mansoori , Zahra Alipoor Gravand, Hamzeh Sarvnaz and Ali Mohammadi *
Affiliation:
- Immunology Research Center, Tabriz University of Medical Sciences, Tabriz,Iran
Keywords:
Angiogenesis, cancer, drug resistance, miR-9, signaling pathway, proliferation.
Abstract: MiRNAs that are characterized by small non-coding RNAs orchestrate the expression of important
genes involved in cancer cell development processes, including apoptosis, proliferation, angiogenesis, metastasis,
and drug resistance at the post-transcriptional level. Dysregulation of miR-9 in various cancers has been reported.
Recently, miR-9 has been considered as a key miRNA in various malignancies. However, its importance
in the pathogenesis of different neoplasms is not yet well defined. Accordingly, this study was conducted
in order to clarify the potential roles of miR-9 in the development of various cancers, prognosis, and treatment
approaches. We have shown that a large number of miR-9 targets play fundamental roles in carcinogenesis, and
that is dysregulated in various cancer cells. Our findings werefound aberrant miR-9 expression in a majority of
cancers. This review article generally emphasizesthe critical roles of miR-9 in cancer cell progression. Additionally,
we intended to investigate the effects of down-regulation or up-regulation of miR-9 in different types of
cancers. It is hoped that a good understanding of the regulatory roles of miR-9 in various cancers ishelpful for
using miR-9 in clinical settings, including prognosis, diagnosis, and miRNA-based target therapy.
