Title:Study of Nutraceuticals and Phytochemicals for the Management of Alzheimer's Disease: A Review
Volume: 19
Issue: 11
Author(s): Syed Sayeed Ahmad, Mohammad Khalid, Mohammad A. Kamal*Kaiser Younis*
Affiliation:
- King Fahd Medical Research Center, King Abdulaziz University, P.O. Box 80216, Jeddah 21589,Saudi Arabia
- Department of Bioengineering, Integral University Lucknow, UP-226026,India
Keywords:
Alzheimer's disease, nutraceuticals, nutrients, phytochemicals, mechanism of AChE in Alzheimer's disease.
Abstract:
Background: Alzheimer's disease (AD) affects several people worldwide and has devastating
impacts on society with a limited number of approaches for its pharmacological treatment.
The main causes of AD are not clear yet. However, the formation of senile plaques, neurofibrillary
tangles, hyper-phosphorylation of tau protein, and disruption of redox homeostasis may cause AD.
These causes have a positive correlation with oxidative stress, producing reactive ions, which are
responsible for altering the physiological condition of the body.
Conclusion: Ongoing research recommended the use of phytochemicals as acetylcholinesterase
inhibitors to hinder the onset and progression of AD. The natural compound structures, including
lignans, flavonoids, tannins, polyphenols, triterpenes, sterols, and alkaloids have anti-inflammatory,
antioxidant, and anti-amyloidogenic properties. The purpose of this article is to provide a brief introduction
to AD along with the use of natural compounds as new therapeutic approaches for its
management.
