Title:Furanodiene: A Novel, Potent, and Multitarget Cancer-fighting Terpenoid
Volume: 27
Issue: 22
Author(s): Rabia Batool, Azhar Rasul*, Ghulam Hussain, Muhammad Ajmal Shah*, Bushra Nageen, Iqra Sarfraz, Muhammad Kashif Zahoor, Ammara Riaz, Aiza Ajaz and Şevki Adem
Affiliation:
- Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad, 38000,Pakistan
- Department of Pharmacognosy, Faculty of Life Sciences, Government College University Faisalabad, 38000,Pakistan
Keywords:
Furanodiene, natural compound, terpenoid, sesquiterpene, anti-cancer, antioxidant, Curcuma.
Abstract: Natural products have served as a limitless reservoir of bioactive scaffolds for drug discovery against
several disorders. Furanodiene is a bioactive natural product isolated from several plants of genus Curcuma. Its
therapeutic potential against cancer, inflammation, and angiogenesis has been well-documented. The current
review is an update about the natural sources and anti-cancer action mechanism of furanodiene. Furanodiene
exerts its anti-cancer effects via induction of apoptosis in several cancer types by modulating MAPKs/ERK,
NF-κB, and Akt pathways. Furanodiene has been systematically studied for its anti-cancer potential. However,
pharmacokinetics, pharmacodynamics, pre-clinical and clinical studies still needed to be conducted to completely
validate the potential of furanodiene for the treatment of cancer.