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摘要
背景:纤维素作为一种储量巨大的天然聚合物,由于其良好的生物相容性、生物降解性、无毒性和优异的力学性能,在医药和生物医学领域得到了广泛的应用。目前应用于医疗领域的耐水金属基和石油基材料存在生物相容性差、成本高的明显问题。因此,具有良好生物相容性和低廉价格的耐水纤维素材料已成为一种有吸引力的替代品。本文综述了近年来纤维素基耐水材料的制备及其在医药和生物医学领域的潜在应用。 方法:综述了纤维素纤维或纸张常用的疏水处理方法。综述了纤维素基防水材料的制备、性能及其在医药和生物医学领域的应用。 结果:常用的纤维素纤维或纸张疏水处理方法分为化学改性(接枝聚合、交联、溶液浇铸或浸涂)、物理化学表面改性(等离子体处理、表面图案处理、静电喷涂和电润湿)和物理处理(静电纺丝、SAS工艺和3D EHD打印)。这些疏水处理的纤维素纤维或纸可制成各种耐水的纤维素基材料,应用于制药辅料、载药两亲胶束、载药复合纤维、疏水生物复合膜/涂层和纸基探测器。它们具有优良的耐水性和生物相容性、低细胞毒性和高载药能力、稳定的药物释放率等特点,可用于水不溶性药物载体、伤口敷料、医疗检测设备等。 结论:目前纤维素基耐水材料主要应用于水不溶性药物输送载体、伤口敷料和医疗诊断等领域,具有广阔的应用前景。然而,这些已报道的抗水纤维素基材料的疏水性和力学性能之间的矛盾限制了其在组织工程等生物医学领域的广泛应用。具有优良机械性能的纤维素基耐水材料的高疏水性将是今后研究的重点。此外,应加强纤维素基耐水材料的临床医学研究。
关键词: 纤维素,疏水处理,耐水的纤维素基材料,医药,生物医学,化学改性。
Current Medicinal Chemistry
Title:A Review of Water-Resistant Cellulose-Based Materials in Pharmaceutical and Biomedical Application
Volume: 28 Issue: 40
关键词: 纤维素,疏水处理,耐水的纤维素基材料,医药,生物医学,化学改性。
摘要:
Background: Cellulose, having huge reserves of natural polymers, has been widely applied in pharmaceutical and biomedicine fields due to its good biocompatibility, biodegradability, non-toxicity and excellent mechanical properties. At present, water- resistant metal-based and petroleum-based materials applied in the medical field have obvious problems of poor biocompatibility and high cost. Therefore, water-resistant cellulose- based materials with good biocompatibility and low price have become an attractive alternative. This review aims to summarize the preparation of water-resistant cellulose- based materials and their potential application in pharmaceutical and biomedical in recent years.
Methods: Common hydrophobic treatments of cellulose fibers or paper were overviewed. The preparation, properties and applications of water-resistant cellulose- based materials in the pharmaceutical and biomedical fields were summarized.
Results: Common hydrophobic treatments of cellulose fibers or paper were divided into chemical modification (graft polymerization, crosslinking, solution casting or dip-coating), physico-chemical surface modifications (plasma treatments, surface patterning, electrostatic spraying and electrowetting) and physical processing (electrostatic spinning, SAS process and 3D EHD printing). These hydrophobically processed cellulose fibers or paper could be prepared into various water-resistant cellulose-based materials and applied in pharmaceutical excipients, drug-loaded amphiphilic micelles, drug-loaded composite fibers, hydrophobic biocomposite film/coatings and paper-based detectors. They presented excellent water resistance and biocompatibility, low cytotoxicity and high drug loading ability, and stable drug release rate, etc., which could be used for water-insoluble drugs carriers, wound dressings, and medical testing equipment.
Conclusion: Currently, water-resistant cellulose-based materials were mainly applied in water-insoluble drugs delivery carriers, wound dressing and medical diagnosis and presented great application prospects. However, the contradiction between hydrophobicity and mechanical properties of these reported water-resistant cellulose-based materials limited their wider application in biomedicine such as tissue engineering. In the future, attention will be focused on the higher hydrophobicity of water-resistant cellulose-based materials with excellent mechanical properties. In addition, clinical medical research of water-resistant cellulose-based materials should be strengthened.
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Cite this article as:
A Review of Water-Resistant Cellulose-Based Materials in Pharmaceutical and Biomedical Application, Current Medicinal Chemistry 2021; 28 (40) . https://dx.doi.org/10.2174/0929867328666210208113354
DOI https://dx.doi.org/10.2174/0929867328666210208113354 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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