Title:Dynamics of Toll-like Receptors Signaling in Skeletal Muscle Atrophy
Volume: 28
Issue: 28
Author(s): Aarti Yadav, Anil Dahuja and Rajesh Dabur*
Affiliation:
- Clinical Research Laboratory, Department of Biochemistry, Maharshi Dayanand University, Rohtak-124001, Haryana,India
Keywords:
Toll-like receptors, skeletal muscle atrophy, inflammation, oxidative stress, pro-inflammatory cytokines.
Abstract: Skeletal muscle atrophy has been characterized as a state of uncontrolled inflammation
and oxidative stress that escalates protein catabolism. Recent advancement supports
impinging signaling molecules in the muscle fibers controlled through toll-like receptors
(TLR). Activated TLR signaling pathways have been identified as inhibitors of muscle mass
and provoke the settings for muscle atrophy. Among them, mainly TLR2 and TLR4 manifest
their presence to exacerbate the release of the pro-inflammatory cytokine to deform the synchronized
muscle programming. The present review enlightens the TLR signaling mediated
muscle loss and the interplay between inflammation and skeletal muscle growth.
