Title:Visible Light Mediated, Catalyst Free, One-Pot Convenient Synthesis of
Dihydropyridines
Volume: 19
Issue: 4
Author(s): Jia-Qi Di, Meng-Nan Chen, Ai-Dong Zhao*Zhan-Hui Zhang*
Affiliation:
- Analysis and Testing Center, Hebei Normal University, Shijiazhuang 050024, P. R. China
- National Demonstration Center for Experimental Chemistry Education, Hebei Key Laboratory of Organic Functional
Molecules, College of Chemistry and Material Science, Hebei Normal University, Shijiazhuang 050024, P. R. China
Keywords:
Catalyst-free, dihydropyridine, green chemistry, multi-component reaction, visible light.
Abstract: A simple, efficient and green protocol has been developed for the synthesis of polysubstituted
dihydropyridines via one-pot, four-component reaction of aldehydes, arylamines, dialkyl acetylenedicarboxylate,
and malononitrile. The reaction was proceeded at room temperature in the absence
of catalyst in aqueous ethyl lactate under visible light irradiation. The main advantages of the present
approach are mild reaction conditions, high yield, no column chromatography, clean reaction profile,
environmentally friendly and sustainability from the economic point of view.
