Title:A Review of Light Sources and Enhanced Targeting for Photodynamic Therapy
Volume: 28
Issue: 31
Author(s): Menghua Xiang, Quanming Zhou, Zihan Shi, Xuan Wang, Mengchu Li, Yan Jia, Shaoyun Li, Fen Yang, Wei Wang, Tongkai Chen, Xiaojun Xu, Bigyan Sharma, Yichu Nie, Qicai Xiao*Liqian Gao*
Affiliation:
- School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen518107,China
- School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen518107,China
Keywords:
Photodynamic therapy, photosensitizers, reactive oxygen species (ROS), light source, oncotherapy, targeting.
Abstract: Photodynamic Therapy (PDT), as a clinically approved modality for the treatment
of various disordered diseases including cancer, has received great advances in recent
years. By preferentially accumulating non-toxic Photosensitizers (PSs) in the pathological
area, and in situ generation of cytotoxic reactive oxygen species (ROS) under local
irradiation by a light source with appropriate wavelength, PDT works in a dual-selective
manner. Over the past decades, numerous studies and reviews on PDT mainly focused
on activable PSs and the newly emerging PSs in PDT. However, to the best of our
knowledge, there are few articles on the systematic introduction of light sources and limited
reports about targeted strategies in PDT. This review comprehensively summarizes
various light sources applied in PDT together with typical enhanced targeting strategies,
and outlines their advantages and disadvantages, respectively. The clinical applications
and future perspectives in light sources are also partly presented and discussed.
