5-Methoxy-1-methyl-2-{[4-(2-hydroxyphenyl)piperazin-1-yl]methyl}-1Hindole (KAD22) with Antioxidant Activity

Agnieszka    A.    Kaczor; Karolina       Wojtunik-Kulesza; Tomasz    M.    Wróbel; Dariusz       Matosiuk; Monika       Pitucha

doi:10.2174/1570178618666210119121438

Abstract

Compound KAD22 (5-methoxy-1-methyl-2-{[4-(2-hydroxyphenyl)piperazin-1-yl]methyl}- 1H-indole) was designed as a potential dopamine D₂ receptor agonist with antioxidant activity for possible treatment of Parkinson’s disease. The compound was obtained from 5-methoxy-1-methyl-1H-indole- 2-carbaldehyde and 2-(piperazin-1-yl)phenol. KAD22 showed no affinity to dopamine D₂ receptor but it is a potent antioxidant. Experimental and computational structural studies (conformational analysis, HOMO and LUMO orbitals, electrostatic potential map, non-covalent interaction plot, spectral properties, ligand-receptor interactions) of KAD22 were performed to address its biological activity.

Keywords: Antioxidant activity, dopamine receptors, indole derivatives, molecular modeling, Parkinson’s disease, structural studies.

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DOI https://dx.doi.org/10.2174/1570178618666210119121438	Print ISSN 1570-1786
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Letters in Organic Chemistry

5-Methoxy-1-methyl-2-{[4-(2-hydroxyphenyl)piperazin-1-yl]methyl}-1Hindole (KAD22) with Antioxidant Activity

Abstract

Graphical Abstract

Carbohydrates: Synthesis, properties and applications

Letters in Organic Chemistry

5-Methoxy-1-methyl-2-{[4-(2-hydroxyphenyl)piperazin-1-yl]methyl}-1Hindole (KAD22) with Antioxidant Activity

Abstract

Graphical Abstract

Call for Papers in Thematic Issues

Carbohydrates: Synthesis, properties and applications

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