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Abstract
Chlorogenic acid (CGA) is a kind of traditional Chinese medicine, abundant in honeysuckle and eucommia, and has a wide range of biological activities, and pharmacological effects. Previous studies have shown that CGA can regulate learning, memory, cognitive ability, coupled with improvement to anxiety, depression, and other post-traumatic stress disorder (PTSD)-like symptoms. This article explores the protective effects of CGA on neurons through its anti-apoptotic effect, inhibition of neuroinflammation and oxidative stress, which may be the mechanisms of its improvement of PTSD-like symptoms. It may provide a new therapeutic strategy for the treatment of PTSD and its comorbidities.
Keywords: Chlorogenic acid, post-traumatic stress disorder, PTSD-like symptoms, learning and memory, apoptosis, oxidative stress.
Current Neuropharmacology
Title:Chlorogenic Acid Improves PTSD-like Symptoms and Associated Mechanisms
Volume: 19 Issue: 12
Author(s): Xing-Dong Chen, Jun-Jie Tang, Shuang Feng, Hua Huang, Feng-Nian Lu, Xiu-Min Lu*Yong-Tang Wang*
Affiliation:
- College of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054,China
- State Key Laboratory of Trauma, Burns and Combined Injury, Daping Hospital, Army Medical University, Chongqing 400042,China
Keywords: Chlorogenic acid, post-traumatic stress disorder, PTSD-like symptoms, learning and memory, apoptosis, oxidative stress.
Abstract: Chlorogenic acid (CGA) is a kind of traditional Chinese medicine, abundant in honeysuckle and eucommia, and has a wide range of biological activities, and pharmacological effects. Previous studies have shown that CGA can regulate learning, memory, cognitive ability, coupled with improvement to anxiety, depression, and other post-traumatic stress disorder (PTSD)-like symptoms. This article explores the protective effects of CGA on neurons through its anti-apoptotic effect, inhibition of neuroinflammation and oxidative stress, which may be the mechanisms of its improvement of PTSD-like symptoms. It may provide a new therapeutic strategy for the treatment of PTSD and its comorbidities.
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Cite this article as:
Chen Xing-Dong , Tang Jun-Jie , Feng Shuang , Huang Hua , Lu Feng-Nian , Lu Xiu-Min *, Wang Yong-Tang *, Chlorogenic Acid Improves PTSD-like Symptoms and Associated Mechanisms, Current Neuropharmacology 2021; 19 (12) . https://dx.doi.org/10.2174/1570159X19666210111155110
DOI https://dx.doi.org/10.2174/1570159X19666210111155110 |
Print ISSN 1570-159X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6190 |
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