Title:Curcumin Nanomicelle Improves Lipid Profile, Stress Oxidative Factors and Inflammatory Markers in Patients Undergoing Coronary Elective Angioplasty; A Randomized Clinical Trial
Volume: 21
Issue: 11
Author(s): Bijan Helli, Hadis Gerami*, Maria Kavianpour, Habib Heybar, Seyed Kianoosh Hosseini and Hossein Khadem Haghighian*
Affiliation:
- Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd,Iran
- Department of Nutrition, School of Health, Qazvin University of Medical Science, Qazvin,Iran
Keywords:
Curcumin, cardiovascular disease, lipid profile, oxidative stress, inflammatory factors, clinical trial.
Abstract:
Background: Curcumin has demonstrated many pharmacological effects including antioxidants,
anti-inflammation, eliminating free radicals, anti-tumor, lipid regulation, and anti-coagulation.
Objective: This study aimed to assess and compare the effects of curcumin and nano-curcumin on
lipid profile, oxidative stress, and inflammatory factors related to patient’s heart.
Methods: This randomized, double-blind, placebo-controlled clinical trial was conducted on 90 patients
undergoing coronary elective angioplasty who were randomly divided into 3 groups. The doses
administered for 8 weeks were a 500 mg capsule of curcumin daily for the first group and an 80
mg capsule of nano-curcumin for the second group. However, the placebo group received capsules
like curcumin. Lipid profile, oxidative stress factors, and inflammatory markers were measured at
the baseline and end of the experiment.
Results: Statistically significant changes were observed in the total cholesterol (TC), triacylglycerol
(TG) and low-density lipoprotein cholesterol (LDL-C) in the intervention groups to the control
group (p<0.05). Curcumin and nano-curcumin supplementation also exhibited significant
changes in plasma levels of total antioxidant capacity (TAC), malondialdehyde (MDA), Superoxide
dismutase (SOD), glutathione peroxidase (GSH-Px), high-sensitivity C-reactive protein (hs-
CRP), Interleukin 1 beta (IL-1β) and tumor necrosis factor-alpha (TNF-α) in comparison to the
placebo (p<0.05). Furthermore, the nano-curcumin group compared to the curcumin group demonstrated
significant changes (p<0.05) in TC, TG, SOD, MDA and TNF-α levels.
Conclusion: The effects of curcumin on nano formula may be better for cardiac patients due to its
high bioavailability.
