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摘要
背景:金基配合物代表了一类新的潜在的金属药物。虽然它们的作用机制尚不完全清楚,但研究表明,金复合物抑制了某些酶的活性。其中,Na、K-atp酶正在成为各种抗癌药物的重要靶点。金(III)复合物对纳米颗粒的功能化可以促进它们传递到细胞中,并使其在目标组织中继续分布。 目的:综述了Na、K-ATP酶与具有代表性和结构相关的细胞毒性金(III)复合物的相互作用。讨论了利用理论方法(DFT和对接研究)结合各种纳米技术基础技术(紫外/可见、拉曼和荧光光谱、CD、AFM、DLS)的实验方法所获得的结果。获得了该酶与金(III)配合物结合后的构象和结构变化的详细信息。对实验确定的反应参数(解离常数和反应化学计量学)进行了理论预测。 结论:本研究结果进一步支持了Na、k-atp酶可能是具有药用意义的细胞毒性金(III)化合物的相关生物分子靶点的观点。
关键词: Na,k-atp酶,金(III)复合物,纳米颗粒,功能化,对接,DFT。
Current Medicinal Chemistry
Title:Na, K-ATPase as a Biological Target for Gold(III) Complexes: A Theoretical and Experimental Approach
Volume: 28 Issue: 23
关键词: Na,k-atp酶,金(III)复合物,纳米颗粒,功能化,对接,DFT。
摘要:
Background: Gold-based complexes represent a new class of potential metallodrugs. Although their action mechanism is not entirely understood, it was shown that gold complexes inhibit some enzymes’ activities. Among them, Na,K-ATPase is emerging as an essential target for various anticancer drugs. The functionalization of nanoparticles by gold(III) complexes could facilitate their delivery into the cells and enable the following of their distribution in the target tissues.
Objective: The paper presents an overview of Na,K-ATPase interaction with representative and structurally related cytotoxic gold(III) complexes. The results obtained by the employment of theoretical methods (DFT and docking studies) combined with the experimental approach involving a variety of nanotechnology-base techniques (UV/Vis, Raman and fluorescence spectroscopy, CD, AFM, DLS) are discussed. Detailed information was obtained on the enzyme’s conformational and structural changes upon binding the gold(III) complexes. The experimentally determined reaction parameters (constants of dissociation and the reaction stoichiometry) were predicted theoretically.
Conclusion: The presented results offer further support to the view that Na,K-ATPase may be a relevant biomolecular target for cytotoxic gold(III) compounds of medicinal interest.
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Cite this article as:
Na, K-ATPase as a Biological Target for Gold(III) Complexes: A Theoretical and Experimental Approach, Current Medicinal Chemistry 2021; 28 (23) . https://dx.doi.org/10.2174/0929867328999210101233801
DOI https://dx.doi.org/10.2174/0929867328999210101233801 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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