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摘要
背景:药物遗传学研究基于个体遗传背景的药物治疗反应。实际上,许多药物遗传学测试有助于预测对不同医疗领域所用药物的反应,从而促成所谓的个性化医疗。 目的:本综述旨在更新有关抗凝剂和抗血小板剂的基因型指导治疗的现有数据。此外,它揭示了心血管药物遗传学实施中的陷阱。 方法:对研究基因型引导的抗凝剂和抗血小板治疗效果的研究文献进行了回顾。 结果:考虑到抗血栓药物的广泛使用,药物遗传学在该领域具有特别重要的意义。几种多态性会影响对抗凝剂和抗血小板剂的反应,现在可以根据它们的鉴定进行测试。 结论:最近的随机临床试验表明,药物遗传学可能成功地有助于优化治疗特别复杂的患者的抗血小板治疗。然而,尽管积累了一些药物遗传学测试的实用性和可行性的证据,但在临床实践中的实施仍然存在一些障碍。
关键词: 血栓栓塞、药物反应、个性化医疗、抗凝剂、抗血小板剂、抗血栓治疗。
Current Medicinal Chemistry
Title:The Role of Pharmacogenetics in Antithrombotic Therapy Management: New Achievements and Barriers Yet to Overcome
Volume: 28 Issue: 32
关键词: 血栓栓塞、药物反应、个性化医疗、抗凝剂、抗血小板剂、抗血栓治疗。
摘要:
Background: Pharmacogenetics investigates the response to pharmacological treatments based on individual genetic background. Actually, numerous pharmacogenetic tests help to predict the response to drugs used in different medical areas, contributing to the so-called personalized medicine.
Objective: This review aims to update the available data on the genotype-guided treatment with both the anticoagulant and antiplatelet agents. Moreover, it sheds light on the pitfalls in the implementation of cardiovascular pharmacogenetics.
Methods: A review of the literature on the studies investigating the effects of the genotype- guided anticoagulant and antiplatelet treatment was performed.
Results: Considering the extensive use of antithrombotic drugs, pharmacogenetics has particular importance in this field. Several polymorphisms influence the response to both anticoagulant and antiplatelet agents, and tests, based on their identification, are now available.
Conclusion: Recent randomized clinical trials demonstrated that pharmacogenetics might successfully contribute to optimizing the antiplatelet therapy also in patients particularly complicated to treat. However, despite accumulating evidence on the utility and feasibility of some pharmacogenetics tests, several barriers still exist in their implementation in clinical practice.
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Cite this article as:
The Role of Pharmacogenetics in Antithrombotic Therapy Management: New Achievements and Barriers Yet to Overcome, Current Medicinal Chemistry 2021; 28 (32) . https://dx.doi.org/10.2174/0929867328666201231124715
DOI https://dx.doi.org/10.2174/0929867328666201231124715 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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