药物遗传学在抗血栓治疗管理中的作用：新成就和尚未克服的障碍

Title:The Role of Pharmacogenetics in Antithrombotic Therapy Management: New Achievements and Barriers Yet to Overcome

Volume: 28 Issue: 32

关键词: 血栓栓塞、药物反应、个性化医疗、抗凝剂、抗血小板剂、抗血栓治疗。

摘要:

Background: Pharmacogenetics investigates the response to pharmacological treatments based on individual genetic background. Actually, numerous pharmacogenetic tests help to predict the response to drugs used in different medical areas, contributing to the so-called personalized medicine.

Objective: This review aims to update the available data on the genotype-guided treatment with both the anticoagulant and antiplatelet agents. Moreover, it sheds light on the pitfalls in the implementation of cardiovascular pharmacogenetics.

Methods: A review of the literature on the studies investigating the effects of the genotype- guided anticoagulant and antiplatelet treatment was performed.

Results: Considering the extensive use of antithrombotic drugs, pharmacogenetics has particular importance in this field. Several polymorphisms influence the response to both anticoagulant and antiplatelet agents, and tests, based on their identification, are now available.

Conclusion: Recent randomized clinical trials demonstrated that pharmacogenetics might successfully contribute to optimizing the antiplatelet therapy also in patients particularly complicated to treat. However, despite accumulating evidence on the utility and feasibility of some pharmacogenetics tests, several barriers still exist in their implementation in clinical practice.

Cite this article as:

The Role of Pharmacogenetics in Antithrombotic Therapy Management: New Achievements and Barriers Yet to Overcome, Current Medicinal Chemistry 2021; 28 (32) . https://dx.doi.org/10.2174/0929867328666201231124715