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The Natural Products Journal

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ISSN (Print): 2210-3155
ISSN (Online): 2210-3163

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Research Article

Anti Diabetic Evaluation of Methanolic Extract of Psoralea corylifolia L. & Psoralea esculenta L. Seeds in Streptozotocin Induced Diabetic Rats and Histopathological Changes in Diabetic Rats Pancreas: A Comparative Study

Author(s): Neeraj Singh, Girendra K. Gautam, Akash Ved* and Karuna S. Shukla*

Volume 12, Issue 3, 2022

Published on: 21 April, 2022

Article ID: e160921189634 Pages: 6

DOI: 10.2174/2210315510999201230114214

Price: $65

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Abstract

Background: Diabetes mellitus is a metabolic disorder which results in a high level of sugar due to inadequacy in insulin secretion. The high sugar level in diabetes is linked to the impairment and dysfunction of the eyes, kidneys, blood vessels, nerves, and heart. In the current research, herbal medicines have been explored because of the side effects associated with oral hypoglycemic therapy of hyperglycemia. Herbal medicines could play a dominant role in the control of diabetes mellitus.

Methods: Methanolic extracts of seeds of Psoralea corylifolia L & Psoralea esculenta L have been screened for both in-vitro and in-vivo anti-hyperglycemic roles using streptozotocin-induced diabetic rats. The methanolic extract of both plants was evaluated for pancreatic tissue studies.

Results: According to the outcomes, a significant decrease in blood glucose level was observed in the diabetic groups treated with methanolic extracts of Psoralea corylifolia L. seeds.

Conclusion: In this study, the methanolic extract of Psoralea corylifolia L. seeds used to evaluate anti-hyperglycemic potential showed appreciably notable and astonishing results when compared with the Glibenclamide. The methanolic extract of Psoralea corylifolia L. seeds has the potential to regulate hyperglycemia in the in-vivo model. Hence, Psoralea corylifolia L. methanol seeds extract may be selected for its anti-hyperglycemic activity.

Keywords: Methanolic extract, antidiabetic activity, Streptozotocin, α-amylase, wistar rats, diabetes mellitus.

Graphical Abstract

[1]
Kamboj, J.; Sharma, S.; Kumar, S. In-vivo Antidiabetic and anti-oxidant potential of Psoraleacoryliofolia seeds in streptozotocin-induced type-2 Diabetic rats. J. Health Sci., 2011, 57, 225-235.
[http://dx.doi.org/10.1248/jhs.57.225]
[2]
Bera, T.K.; Ali, K.M.; Jana, K.; Ghosh, A. Protective effect of seed of Psoralea coryliofolia (Som raji) and seed of Trigonella foenumgraecum L. (methi). Pharmacol. Res., 2013, 5, 277-285.
[3]
Homma, Y. Predictors of atherosclerosis. J. Atheroscler. Thromb., 2004, 11(5), 265-270.
[http://dx.doi.org/10.5551/jat.11.265] [PMID: 15557708]
[4]
Miura, H.; Nishida, H.; Linuma, M. Effect of crude fractions of Psoraleacorylifolia seed extract on bone calcification. Planta Med., 1996, 62(2), 150-153.
[http://dx.doi.org/10.1055/s-2006-957839] [PMID: 8657749]
[5]
Kotiyal, J.P.; Sharma, D.P. Phytochemical studies of Psoralea species. Bulletin of Medico- Ethnobotanical Res., 1992, 13, 209-223.
[6]
Tsai, W.J.; Hsin, W.C.; Chen, C.C. Antiplatelet flavonoids from seeds of Psoralea corylifolia. J. Nat. Prod., 1996, 59(7), 671-672.
[http://dx.doi.org/10.1021/np960157y] [PMID: 8759164]
[7]
Bensky, D.; Gamble, A. Chinese Herbal Medicine: Mat. Medica, Revised edition; East-land Press, Washington, 1993, pp. 344-345.
[8]
Chino, M.; Sato, K.; Yamazaki, T.; Maitani, T. [Constituent of natural food additive hokosshi extract and an analytical method for the additive in foods]. ShokuhinEiseigakuZasshi., 2002, 43(6), 352-355.
[http://dx.doi.org/10.3358/shokueishi.43.352] [PMID: 12635337]
[9]
Khatune, N.A.; Islam, M.E.; Haque, M.E.; Khondkar, P.; Rahman, M.M. Antibacterial compounds from the seeds of Psoralea corylifolia. Fitoterapia, 2004, 75(2), 228-230.
[http://dx.doi.org/10.1016/j.fitote.2003.12.018] [PMID: 15030932]
[10]
Zhu, D.Y.; Chen, Z.X.; Zhou, B.N.; Liu, J.S.; Huang, B.S.; Xie, Y.Y.; Zeng, G.F. Studies on chemical constituents of Bu-Gu-Zhi, the seeds of Psoraleacorylifolia. ActaPharmacol. Sin., 1979, 14, 605-611.
[PMID: 539427]
[11]
Moerman. D.. Native American Ethnobotany; Timber Press: Oregon, 1998.
[12]
Modak, M.; Dixit, P.; Londhe, J. Indian herbs and herbal drugs used for the treatment of diabetes. J. Clin. Biochem. Nutr., 2007, 40(3), 163-173.
[http://dx.doi.org/10.3164/jcbn.40.163] [PMID: 18398493]
[13]
Sabitha, V.; Ramachandran, S.; Naveen, K.R.; Panneerselvam, K. Antidiabetic and antihyperlipidemic potential of Abelmoschus esculentus (L.) Moench. in streptozotocin-induced diabetic rats. J. Pharm. Bioallied Sci., 2011, 3(3), 397-402.
[http://dx.doi.org/10.4103/0975-7406.84447] [PMID: 21966160]
[14]
Shukla, A.; Bukhariya, V.; Mehta, J. Herbal remedies for diabetes: an overview. Int. J. Biol. Adv. Res., 2011, 2, 57-58.
[http://dx.doi.org/10.7439/ijbar.v2i1.22]
[15]
Li, W.L.; Zheng, H.C.; Bukuru, J.; De Kimpe, N. Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus. J Ethnopharmacol., 2004, 92(1), 1-21.
[http://dx.doi.org/10.1016/j.jep.2003.12.031] [PMID: 15099842]
[16]
Sy, G.Y.; Cissé, A.; Nongonierma, R.B.; Sarr, M.; Mbodj, N.A.; Faye, B. Hypoglycaemic and antidiabetic activity of acetonic extract of Vernonia colorata leaves in normoglycemic and alloxan induced diabetic rats. J. Ethnopharmacol., 2005, 98(1-2), 171-175.
[http://dx.doi.org/10.1016/j.jep.2005.01.024] [PMID: 15763379]
[17]
Zia, T.; Hasnain, S.N.; Hasan, S.K. Evaluation of the oral hypoglycaemic effect of Trigonella foenum-graecum L. (methi) in normal mice. J. Ethnopharmacol., 2001, 75(2-3), 191-195.
[http://dx.doi.org/10.1016/S0378-8741(01)00186-6] [PMID: 11297850]
[18]
Gautam, G.K.; Vidyasagar, G.; Dwivedi, S.C. Study on medicinal plants from indian origin; Lambert Academic Publishing, 2012, p. 70.
[19]
Verma, A.K.; Singh, H.; Satyanarayana, M. Flavone based novel antidiabetic and antidyslipidemic agents. J. Med. Chem., 2012, 55(10), 4551-4567.
[http://dx.doi.org/10.1021/jm201107g] [PMID: 22524508]
[20]
Narkhede, M.B.; Ajimire, P.V.; Wagh, A.E.; Mohan, M.; Shivashanmugam, A.T. In vitro antidiabetic activity of Caesalpina digyna (R.) methanol root extract. Asian J. Plant Sci. Res., 2011, 1(2), 101-106.
[21]
Tapas, A.; Sakarkar, D.; Kakde, R. Flavonoids as Nutraceuticals: A Review. Trop. J. Pharm. Res., 2008, 7, 1089-1099.
[http://dx.doi.org/10.4314/tjpr.v7i3.14693]
[22]
Thaipong, K.; Boonprakob, U.; Crosby, K. Comparison of ABTS, DPPH, FRAP, and ORAC assays for estimating antioxidant activity from guava fruit extracts. J. Food Compos. Anal., 2006, 19(1), 669-675.
[http://dx.doi.org/10.1016/j.jfca.2006.01.003]
[23]
Kaushik, P.; Kaushik, D.; Lal, S. In vivo antioxidant activity of plant Abutilon indicum. J. Pharm. Educ. Res., 2011, 2(1), 50-53.
[24]
Krutika, T.; Leena, P.; Dnyanesh, L. In vitro models for antidiabetic activity assessment. Int. J. Pharm. Biomed. Res., 2012, 3, 730-733.
[25]
Bnouham, M.; Ziyyat, A.; Mekhfi, H. Medicinal plants with potential antidiabetic activity-A review of ten years of herbal medicine research (1990-2000). Int. J. Diabetes Metab., 2006, 14, 1-25.
[http://dx.doi.org/10.1159/000497588]
[26]
Calderón-Montaño, J.M.; Burgos-Morón, E.; Pérez-Guerrero, C.; López-Lázaro, M. A review on the dietary flavonoid kaempferol. Mini Rev. Med. Chem., 2011, 11(4), 298-344.
[http://dx.doi.org/10.2174/138955711795305335] [PMID: 21428901]
[27]
Habtemariam, S. The anti-obesity potential of sigmoidin A. Nat. Prod. Commun., 2011, 6, 201-203.
[PMID: 21425674]
[28]
Gautam, G.K.; Vidhyasagar, G.; Dwivedi, S.C.; Dwivedi, S. Antidiabetic activity of aqueous and methanolic extract of Abutilon muticum. Int. J. Pharm. Teach. Prac., 2013, 4, 522-526.
[29]
Amidon, G.L.; Lennernäs, H.; Shah, V.P.; Crison, J.R. A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability. Pharm. Res., 1995, 12(3), 413-420.
[http://dx.doi.org/10.1023/A:1016212804288] [PMID: 7617530]
[30]
Ming, J.; Hui, Y.; Yan, W. In vitro and in vivo studies of antioxidant activities of flavonoids from Adiantum capillus-veneris L. Afr. J. Pharm. Pharmacol., 2011, 5, 2079-2085.
[31]
Tozuka, Y.; Imono, M.; Uchiyama, H.; Takeuchi, H. A novel application of α-glucosyl hesperidin for nanoparticle formation of active pharmaceutical ingredients by dry grinding. Eur. J. Pharm. Biopharm., 2011, 79(3), 559-565.
[http://dx.doi.org/10.1016/j.ejpb.2011.07.006] [PMID: 21820051]
[32]
Senthil kumar, K.; Poluru, R.; Sathish, S. A Comparative study on the Antidiabetic effect of Nelumbo nucifera and Glimpiride in streptozotocine induced diabetic rats. ‎. Int. J. Pharma Bio Sci., 2011, 2, 63-69.
[33]
Sharma, N.; Garg, V. Antihyperglycemic and antioxidant effect of hydroethanolic extract of Butea monosperma bark in diabetic mice. Indian J. Biochem. Biophys., 2012, 49(1), 55-62.
[PMID: 22435145]
[34]
Fang, X.K.; Gao, J.; Zhu, D.N. Kaempferol and quercetin isolated from Euonymus alatus improve glucose uptake of 3T3-L1 cells without adipogenesis activity. Life Sci., 2008, 82(11-12), 615-622.
[http://dx.doi.org/10.1016/j.lfs.2007.12.021] [PMID: 18262572]
[35]
Hamden, K.; Carreau, S.; Boujbiha, M.A.; Lajmi, S.; Aloulou, D.; Kchaou, D.; Elfeki, A. Hyperglycaemia, stress oxidant, liver dysfunction and histological changes in diabetic male rat pancreas and liver: protective effect of 17 β-estradiol. Steroids, 2008, 73(5), 495-501.
[http://dx.doi.org/10.1016/j.steroids.2007.12.026] [PMID: 18291430]

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