Title:Competing Endogenous RNAs (CeRNAs): Novel Network in Neurological Disorders
Volume: 28
Issue: 29
Author(s): Sadra Samavarchi Tehrani, Reyhane Ebrahimi, Atiyeh Al-e-Ahmad, Ghodratollah Panahi, Reza Meshkani, Simin Younesi, Payam Saadat and Hadi Parsian*
Affiliation:
- Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol,Iran
Keywords:
Competing endogenous RNAs (CeRNAs), MicroRNAs, Long non-coding RNAs, Pseudogenes, CircularRNAs,
Neurological disorders.
Abstract: Neurological disorders (NDs) comprise a broad range of diseases affecting
both central and peripheral nervous systems. These complex multifactorial diseases have
a high rate of mortality all over the world, particularly in aged people. Today, new evidence
drove our attention to the notable role of noncoding RNAs (ncRNAs) in the progression
of NDs. Remarkably, recent studies showed that there are close communication
networks among RNA transcripts such as mRNAs, long non-coding RNAs (lncRNAs),
circular RNAs (circRNAs), and pseudogenes for regulating each other’s expression
through competing for shared sequences in microRNAs (miRs). This concept is a new
area of ongoing research recognized as competing endogenous RNA (ceRNA) hypothesis.
CeRNAs are novel regulatory molecules in a wide range of biological stages and
pathological contexts. Indeed, the disruption of ceRNA networks (ceRNETs) may affect
neural development genes and induce neuropathological changes leading to the development
of NDs. Because of this, identifying the correlation of ceRNETs with NDs will
open a new window for expanding our knowledge about this field of science, as well as
creating novel roads for developing specific diagnostic biomarkers for NDs management.
Owing to these unique features, exploring the exact role of ceRNAs is a hot topic in NDs
investigations. Hence, in this review, we will summarize the evidence supporting ceRNETs
in the regulation of NDs-related gene expression.
