摘要
骨关节炎 (OA) 是一种软骨和骨骼的退行性疾病,会严重影响老年人群的生活质量。然而,目前还没有开发出理想的治疗策略来预防 OA 进展。细胞疗法,如软骨细胞和 MSC 移植,已在临床试验中得到广泛测试和评估。然而,迄今为止,关节内注射干细胞在 OA 中的临床疗效尚未得到令人信服的证明。最近的研究表明,外泌体,一种细胞外囊泡(EVs)在 OA 的发病机制中起着重要的调节作用,表明外泌体在 OA 治疗中的前瞻性治疗应用。在这篇综述中,我们系统地总结了源自 MSCs 和软骨细胞的外泌体对软骨再生的旁分泌作用、外泌体作为 OA 治疗的载体的使用、此类治疗在 OA 动物模型中的有效性以及外泌体的未来前景——介导的药物递送作为 OA 的无细胞疗法。
关键词: 外泌体、靶向药物递送、间充质干细胞、软骨细胞、骨关节炎、细胞外囊泡。
Current Medicinal Chemistry
Title:Exosome-Mediated Drug Delivery for Cell-Free Therapy of Osteoarthritis
Volume: 28 Issue: 31
关键词: 外泌体、靶向药物递送、间充质干细胞、软骨细胞、骨关节炎、细胞外囊泡。
摘要: Osteoarthritis (OA) is a degenerative disease of cartilage and bones, which results in severely compromised quality of life in the aged population. However, currently, no ideal treatment strategies have been developed to prevent OA progression. Cell therapies, such as chondrocyte and MSC transplantation, have been extensively tested and evaluated in clinical trials. Yet, to day, the clinical efficacy of articular injection of stem cells in OA has not been convincingly demonstrated. Recent studies have indicated that exosomes, one type of Extracellular Vesicles (EVs) play an important regulatory role in the pathogenesis of OA, suggesting the prospective therapeutic application of exosomes in OA treatment. In this review, we systematically summarized the paracrine effects of exosomes derived from MSCs and chondrocytes on cartilage regeneration, the use of exosomes as a delivery vehicle for OA treatment, the effectiveness of such treatments in OA animal models, and the future perspective of exosome-mediated drug delivery as a cell- free therapy of OA.
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Exosome-Mediated Drug Delivery for Cell-Free Therapy of Osteoarthritis, Current Medicinal Chemistry 2021; 28 (31) . https://dx.doi.org/10.2174/0929867327666201118161232
DOI https://dx.doi.org/10.2174/0929867327666201118161232 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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