Title:Exosome-Mediated Drug Delivery for Cell-Free Therapy of Osteoarthritis
Volume: 28
Issue: 31
Author(s): Li Duan*, Xiao Xu, Limei Xu, Hongfei Chen, Xingfu Li, Murad Alahdal, Yin Xiao, Yujie Liang*Jiang Xia*
Affiliation:
- Department of Orthopedics, Shenzhen Intelligent Orthopaedics and Biomedical Innovation Platform, Guangdong Artificial Intelligence Biomedical Innovation Platform, Shenzhen Second People’s Hospital, the First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen 518035,China
- Department of Chemistry, The Chinese University of Hong Kong, Shatin, Hong Kong SAR,China
- Department of Chemistry, The Chinese University of Hong Kong, Shatin, Hong Kong SAR,China
Keywords:
Exosome, targeted drug delivery, mesenchymal stem cells, chondrocytes, osteoarthritis, extracellular
vesicles.
Abstract: Osteoarthritis (OA) is a degenerative disease of cartilage and bones, which results
in severely compromised quality of life in the aged population. However, currently,
no ideal treatment strategies have been developed to prevent OA progression. Cell therapies,
such as chondrocyte and MSC transplantation, have been extensively tested and
evaluated in clinical trials. Yet, to day, the clinical efficacy of articular injection of stem
cells in OA has not been convincingly demonstrated. Recent studies have indicated that
exosomes, one type of Extracellular Vesicles (EVs) play an important regulatory role in
the pathogenesis of OA, suggesting the prospective therapeutic application of exosomes
in OA treatment. In this review, we systematically summarized the paracrine effects of
exosomes derived from MSCs and chondrocytes on cartilage regeneration, the use of exosomes
as a delivery vehicle for OA treatment, the effectiveness of such treatments in OA
animal models, and the future perspective of exosome-mediated drug delivery as a cell-
free therapy of OA.
