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摘要
尽管临床实践中使用了许多策略和参数,但急性肾损伤(AKI)的发病率和死亡率仍然很高,预后不良。随着分子生物学的发展,维生素D和维生素D受体(VDR)在AKI中的作用越来越受到重视。许多研究表明,维生素D缺乏是临床和实验性AKI的危险因素,维生素D/VDR可能是AKI的一个有前途的治疗靶点。然而,需要更多的定性临床研究,为维生素D和VDR激动剂的未来临床应用提供更有力的证据。给药途径和剂量等问题也有待更多关注。本文旨在总结维生素D/VDR在AKI中的作用,并对其治疗潜力提供一些新的见解。
关键词: 维生素D,维生素D受体,急性肾损伤,缺乏,治疗靶点,剂量。
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