Title:UCP2 and CFH Gene Variants with Genetic Susceptibility to Schizophrenia in Turkish Population
Volume: 21
Issue: 11
Author(s): Ayse Feyda Nursal*, Pinar Cetinay Aydin, Mustafa Pehlivan, Ulgen Sever and Sacide Pehlivan
Affiliation:
- Department of Medical Genetics, Faculty of Medicine, Hitit University, Çorum,Turkey
Keywords:
Schizophrenia, uncoupling protein 2, complement factor H, variant, Turkish population, genome-wide association studies.Schizophrenia, genome-wide association studies.
Abstract:
Objective: Schizophrenia (Sch) is a complex, multifactorial psychiatric disorder. Growing
evidence shows that oxidative damage and immunological dysfunction exist in the Sch physiopathology.
In the present study, we aimed to evaluate whether the Uncoupling protein 2 and Complement
factor H gene variants play any role in susceptibility to Sch.
Methods: This study was carried out on 200 individuals (100 Sch patients and 100 healthy controls).
Genomic DNA was extracted from blood samples. UCP2-866G /A (rs659366) and CFHY402H
variants were analyzed by PCR-RFLP analysis.
Results: The UCP2 -866G/A variant G/G genotype and G allele were associated significantly with
increased risk of Sch (p=0.001, p=0.001, respectively). The subjects were carrying UCP2 -866G/A
variant G/G genotype had 4.377-fold increased risk for Sch. There was no significant difference between
the groups for the genotype and allele frequencies of the CFH Y402H variant (p>0.05). The
observed genotype counts deviated significantly from those expected in Sch patients according to
the HWE for UCP2 -866G/A variant (p=0.001).
Conclusion: We present the first results investigating UCP2 -866G/A/ and CFH Y402H variants
for susceptibility to Sch in a Turkish population. These results indicate that the UCP2 -866G/A, but
not CFH Y402H variant, might play an important role in the development of Sch.
