Title:Recent Development of Novel HDAC6 Isoform-selective Inhibitors
Volume: 28
Issue: 21
Author(s): Yunpeng Zhao, Tao Liang, Xuben Hou*Hao Fang*
Affiliation:
- Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44, Wenhuaxi Road, Jinan, Shandong, 250012,China
- Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44, Wenhuaxi Road, Jinan, Shandong, 250012,China
Keywords:
post-transcription modification, HDAC6, structure, cancer, selective inhibitor, histone deacetylation.
Abstract: As an important post-transcription modification, histone deacetylation plays
significant roles in chromatin remodeling and gene expression. The aberrant modification
of histone deacetylation leads to various diseases. As a critical member of histone
deacetylase (HDAC), HDAC6 serves as a key modulator in many physiological processes.
Abnormal expression of HDAC6 gives rise to cancer, neurodegeneration and other
diseases. Here, we have reviewed recent advances in physiological, protein structure and
development of HDAC6 selective inhibitors.
