Title:Phenyl Substituted Thiazole Linked 1, 2, 4-triazole Derivatives: Synthesis and Their Biological Evaluation
Volume: 18
Issue: 9
Author(s): Sonika Jain, Esha Dhall, Meenu Devi, Swapnil Sharma, Jaya Dwivedi and Sanjeev Kumar Sahu*
Affiliation:
- School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab,India
Keywords:
Schiff bases, cyclizations, drug research, heterocycles, mass spectroscopy, antibacterial activity.
Abstract:
Synthesize and evaluate some phenyl substituted thiazole linked 1, 2, 4-triazole derivatives as
antimicrobial agents.
Compounds containing 1, 2, 4-triazole moieties are widely used as antimicrobial and antifungal agents
whereas thiazole is another heterocyclic ring exhibiting various pharmacological actions. It is interesting
to incorporate different bioactive pharmacophores in the same molecular framework to examine cumulative
effect exerted by the moiety. This hypothesis was applied in research work by having triazole and
thiazole in the same molecular framework.
The present work was mainly focused on synthesis of some 1, 2, 4-triazole derivatives linking with phenyl
substituted thiazole nucleus and their evaluation for biological activity.
The compounds (8a-8j) were synthesized as per design scheme and elucidated their structures using
different spectroscopic data of IR, 1HNMR, 13CNMR & mass spectroscopy. These synthesized
derivatives were evaluated for their antibacterial activity using broth dilution assay. Further, mechanism
of action of test compounds was examined using protein leakage assay.
All the spectral data were confirmed the synthesis of phenyl substituted thiazole linked 1, 2, 4- triazole
derivatives and some of them exhibited significant antimicrobial activity.
Amongst all compound 8c showed most potent activity with lowest IC50 values 180 μg/ml and 120
μg/ml against S. aureus & amp; B. cereus respectively. Whereas compound 8j demonstrated strong
inhibitory activities only against negative strains P. aeruginosa and E. coli with lowest IC50 values
240 μg/mL and 200μg/mL respectively.
