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摘要
未折叠蛋白反应(UPR)的细胞间传递是最近在细胞生物学中最令人兴奋的观察结果之一。在细胞培养中诱导UPR反应的最有效的工具之一是处理特定的化合物,导致内质网中错误折叠蛋白的积累。在本文中,我们讨论了关于这种方法的应用和实验人工制品的可能来源的相反意见。
关键词: 内质网、未折叠蛋白反应、条件培养基、UPR、未折叠蛋白、细胞间细胞传递、反应。
Current Medicinal Chemistry
Title:Cell-to-Cell Transmission of the Unfolded Protein Response - Is it a Real Phenomenon?
Volume: 28 Issue: 22
关键词: 内质网、未折叠蛋白反应、条件培养基、UPR、未折叠蛋白、细胞间细胞传递、反应。
摘要: Cell-to-cell transmission of the unfolded protein response (UPR) is one of the most exciting observations recently made in cell biology. One of the most efficient tools to induce UPR response in cell culture is treatment with specific compounds leading to accumulation of misfolded proteins in endoplasmic reticulum. In this article we discussed opposite opinions regarding application of this approach and possible sources of experimental artefacts.
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Cite this article as:
Cell-to-Cell Transmission of the Unfolded Protein Response - Is it a Real Phenomenon?, Current Medicinal Chemistry 2021; 28 (22) . https://dx.doi.org/10.2174/0929867327999201105163402
DOI https://dx.doi.org/10.2174/0929867327999201105163402 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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