Abstract
Cell-to-cell transmission of the unfolded protein response (UPR) is one of the most exciting observations recently made in cell biology. One of the most efficient tools to induce UPR response in cell culture is treatment with specific compounds leading to accumulation of misfolded proteins in endoplasmic reticulum. In this article we discussed opposite opinions regarding application of this approach and possible sources of experimental artefacts.
Keywords: Endoplasmic reticulum, unfolded protein response, conditioned media, UPR, unfolded protein, cell-tocell transmission, response.
Current Medicinal Chemistry
Title:Cell-to-Cell Transmission of the Unfolded Protein Response - Is it a Real Phenomenon?
Volume: 28 Issue: 22
Author(s): Maria Bozko and Przemyslaw Bozko*
Affiliation:
- Department of Internal Medicine I, Universitätsklinikum Tübingen, Tübingen,Germany
Keywords: Endoplasmic reticulum, unfolded protein response, conditioned media, UPR, unfolded protein, cell-tocell transmission, response.
Abstract: Cell-to-cell transmission of the unfolded protein response (UPR) is one of the most exciting observations recently made in cell biology. One of the most efficient tools to induce UPR response in cell culture is treatment with specific compounds leading to accumulation of misfolded proteins in endoplasmic reticulum. In this article we discussed opposite opinions regarding application of this approach and possible sources of experimental artefacts.
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Cite this article as:
Bozko Maria and Bozko Przemyslaw *, Cell-to-Cell Transmission of the Unfolded Protein Response - Is it a Real Phenomenon?, Current Medicinal Chemistry 2021; 28 (22) . https://dx.doi.org/10.2174/0929867327999201105163402
DOI https://dx.doi.org/10.2174/0929867327999201105163402 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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