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Review Article

细胞内钙稳态与肾脏疾病

卷 28, 期 18, 2021

发表于: 02 November, 2020

页: [3647 - 3665] 页: 19

弟呕挨: 10.2174/0929867327666201102114257

价格: $65

Open Access Journals Promotions 2
摘要

肾脏疾病是一个严重的健康问题，给我们的医疗保健系统带来负担。找到各类肾脏疾病的准确发病机制，为这些疾病患者的精准治疗提供指导至关重要。然而，这些疾病的确切分子机制尚未完全了解。肾细胞内钙稳态紊乱通过促进细胞增殖，刺激细胞外基质积累，在各种肾小球疾病，如原发性肾小球疾病、糖尿病肾病、急性肾损伤和多囊肾病的发生发展中起着基础性作用。加重足细胞损伤，扰乱细胞能量学以及失调细胞存活和死亡动力学。因此，防止特定肾脏细胞(如小管细胞、足细胞和系膜细胞)的钙稳态紊乱成为肾脏疾病治疗中最有前途的治疗策略之一。内质网和线粒体是这一过程中两个重要的细胞器。钙离子在内质网和线粒体结合处循环，这两个细胞器称为线粒体相关内质网膜，维持钙稳态。细胞钙稳态的药理学调节可视为肾脏疾病的一种新的治疗方法。在这里，我们将介绍生理条件下的钙稳态和肾脏疾病中钙稳态的紊乱。我们将重点讨论肾脏细胞(包括小管细胞、足细胞和系膜细胞)的钙稳态调节，特别是这些肾脏细胞的线粒体相关内质网膜。

关键词: 钙稳态，细胞，肾脏，内质网，线粒体，线粒体相关内质网膜

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