Title:Association of Hippo Signalling Pathway with Epigenetic Changes in Cancer Cells and Therapeutic Approaches: A Review
Volume: 21
Issue: 12
Author(s): Roza Motavalli, Faroogh Marofi, Maryam Nasimi, Mehdi Yousefi and Farhad M. Khiavi*
Affiliation:
- Department of Virology, Pasteur Institute of Iran, Tehran,Iran
Keywords:
Hippo signalling, cancer cell, tissue regeneration, HDACs, lncRNA, DNA methylation.
Abstract: Hippo signalling pathway that is evolutionarily conserved affects diver’s pathology and physiology
processes, including tissue repair, wound healing, tissue size and tissue regeneration. Epigenetic changes are
post-translational modifications in DNA proteins and histones. Epigenetic changes including histone acetylation
and deacetylation, miRNAs dysregulation, and aberrant DNA methylation, inflammatory genes actives abnormal
in Hippo signaling pathway. Using some treatments, including Histone Deacetylases (HDACs), herbal
composition, siRNAs and long non-coding RNA (lncRNA) for suppressing cancer cells by targeting Hippo
pathways, may open new views in cancer target therapy fields. The aim of this review study is firstly to
demonstrate the importance of Hippo signalling and its association with epigenetic changes in cancer and then to
demonstrate progress in targeting Hippo signalling in cancer therapy.