摘要
帕罗西汀是一种有效的血清素再摄取抑制剂,广泛用于治疗抑郁症和其他神经系统疾病。 帕罗西汀的合成以及制备具有特定取代模式的衍生物的可能性,使其可用作生物探针,这是一个有吸引力的话题,尤其是对从事神经科学研究的药物化学家而言。 考虑到过去十年在帕罗西汀全合成方面开展的大量工作,本综述总结了该领域最重要的贡献,根据用作起始材料的试剂进行组织。 大多数方法允许分 4-9 个步骤制备帕罗西汀,总产率为 9-66%。 尽管在这一领域取得了进展,但仍有改进的空间,寻找新的环保和可持续的合成替代品。
关键词: _阿罗西汀、合成方法、N-取代哌啶酮、4-氟苯甲醛、取代吡啶、α
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