Title:Comparison of Salivary Antioxidants and Oxidative Stress Status in Gestational Diabetes Mellitus and Healthy Pregnant Women
Volume: 21
Issue: 8
Author(s): Fatemeh Ahmadi-Motamayel*, Shima Fathi, Mohammad Taghi Goodarzi, Shiva Borzouei, Jalal Poorolajal and Yasamin Barakian
Affiliation:
- Dental Research Center and Research Center for Molecular Medicine, Department of Oral Medicine, Hamadan University of Medical Sciences, Hamadan,Iran
Keywords:
Gestational diabetes mellitus, oxidative stress, antioxidant, malondialdeyde, saliva, pregnant women.
Abstract:
Background: One of the most common complications of pregnant women is gestational
diabetes mellitus (GDM). Oxidative stress can play an important role in GDM.
Objective: The aim of this study was to evaluate salivary antioxidants and oxidative stress markers
in GDM.
Methods: Twenty pregnant women with GDM and 20 healthy pregnant women with normal blood
glucose test participated in this study. Five mL of unstimulated saliva samples were collected. Spectrophotometric
assay was carried out for sialo-chemical analysis. Stata software was used for data
analysis.
Results: The GDM group exhibited no significant difference in salivary total antioxidant capacity
and malondialdehyde compared to the healthy control group. All antioxidants markers, the uric
acid, total antioxidant, peroxidase and catalase, decreased in GDM group that the difference of peroxidase
and catalase was statistically significant. All of oxidative stress markers, the salivary
malondialdehyde, total oxidative stress and total thiol, increased in GDM group. GDM group exhibited
significantly higher salivary total oxidative stress levels.
Conclusion: Catalase level was significantly lower and total oxidative stress was significantly higher.
These two markers might have significant importance and might exhibit early changes compared
to other factors in GDM. Some salivary antioxidants might have diagnostic, prognostic or
therapeutic implications in GDM. Other studies with large sample size on salivary and blood samples
need to be done to confirm these properties and salivary samples using instead of blood samples
in GDM biomarkers changes.
