Title:The Mitochondrion-Targeted Antioxidants in Kidney Disease
Volume: 28
Issue: 21
Author(s): Xinrui Li, Liang Ma*Ping Fu
Affiliation:
- Division of Nephrology and National Clinical Research Center for Geriatrics, Kidney Research Institute, West China Hospital of Sichuan University, Chengdu 610041,China
Keywords:
mitochondria-targeted, antioxidant, kidney disease, triphenylphosphonium, Szeto-Schiller peptides,
hemigramicidin.
Abstract: Mitochondria are a potent source of cellular reactive oxygen species (ROS)
and are vulnerable to oxidative damage. Mitochondria dysfunction could result in adenosine
triphosphate (ATP) decrease and cell death. The kidney is an ATP-consuming organ,
and the relationship between mitochondrial dysfunction and renal disease has been
long noted. Mitochondrial targeting is a novel strategy for kidney diseases. At present,
there are several ways to target mitochondria, such as the addition of a triphenylphosphonium
cation, mitochondria-targeted peptides, and nanocarrier. There are also a variety of
choices for the payload, such as nitroxides, quinone derivates, vitamins and so on. This
review summarized the chemical and also clinical characteristics of various mitochondria-
targeted antioxidants and focused on their application and perspectives in kidney
diseases.
