Title:The Neuroprotective Role of Neuroserpin in Ischemic and Hemorrhagic Stroke
Volume: 19
Issue: 8
Author(s): Shanshan Ding, Qiliang Chen, Huaqin Chen, Bangshui Luo, Candong Li, Liang Wang and Tetsuya Asakawa*
Affiliation:
- Research Base of Traditional Chinese Medicine Syndrome, Fujian University of Traditional Chinese Medicine, Fuzhou 350122,China
Keywords:
Stroke, tPA, neuroserpin, neuroprotective effects, neuroinflammation, blood-brain barrier.
Abstract: Tissue plasminogen activator (tPA) is commonly used to treat acute ischemic stroke
within an appropriate therapeutic window. Its inhibitor, neuroserpin (NSP), is reported to exhibit
neuroprotective effects on stroke. This review aims to summarize, from literature, the available
evidence, potential mechanisms, and knowledge limitations regarding the neuroprotective role of
NSP in stroke. All the available evidence indicates that the regulation of the inflammatory response
may play a key role in the mechanisms of NSP, which involve all the constituents of the neuroimmune
axis. The neuroinflammatory response triggered by stroke can be reversed by NSP, with
complicated mechanisms such as maintenance and reconstruction of the structure and function of
the blood-brain barrier (BBB), protection of the cells in the central nervous system, and suppression
of cell death in both ischemic and hemorrhagic stroke. Moreover, available evidence strongly suggests
a tPA-independent mechanism is involved in NSP. However, there are many important issues
that are still unclear and need further investigation, such as the effects of NSP on hemorrhagic
stroke, the role of the tPA-independent neuroprotective mechanisms, and the clinical application
prospects of NSP. We believe our work will be helpful to further understand the neuroprotective
role of NSP.