Effect of Barley Grain on Memory and Brain’s Oxidative Stress Factors in Male Rats

Title:Effect of Barley Grain on Memory and Brain’s Oxidative Stress Factors in Male Rats

Volume: 11 Issue: 5

Author(s): Batool Shakiba-Jam, Azam Moghani, Marzieh Kafami*, Mahmoud Hosseini, Masoud Hosseinzadeh and Adel Naeimi

Affiliation:

• Non-Communicable Disease Research Center, Sabzevar University of Medical Sciences, Sabzevar,Iran

Keywords: Barley, scopolamine, memory, oxidative stress, malondialdehyde, antioxidant phenols, dementia.

Abstract:

Background & Objective: Barley is widely used as a major staple of human food and animal feed. Several antioxidant phenols are found in barely, which have scavenging properties. The present study aimed to assess the protective effects of barley seed against the oxidative damage of brain tissues in a scopolamine-induced memory impairment model.

Materials and Methods: In total, 32 male albino rats (mean weight: 250±10 g) were divided into four groups of saline (control), scopolamine, barley seed (100 mg/kg) with scopolamine, and barley seed alone. The spatial memory function was assessed using the Morris water maze.

Results: Compared to the scopolamine group, barley seed could decrease the escape latency time in the treated rats, while the time spent and distance traveled in the target quadrant on the probe trial increased. Moreover, barley seed could increase the malondialdehyde concentration in the hippocampus and cortical tissues, while the thiol content was observed to decrease.

Conclusion: According to the results, the use of dietary barley seed could improve the memory function in dementia associated with increased oxidative stress.

Cite this article as:

Shakiba-Jam Batool , Moghani Azam , Kafami Marzieh *, Hosseini Mahmoud , Hosseinzadeh Masoud and Naeimi Adel , Effect of Barley Grain on Memory and Brain’s Oxidative Stress Factors in Male Rats, The Natural Products Journal 2021; 11 (5) : e061020186686 . https://dx.doi.org/10.2174/2210315510999201006200857