摘要
Covid-19是一种新兴的暴发,类似于以前由严重急性呼吸系统综合征(SARS)和中东呼吸系统综合征(MERS)引起的大流行。到目前为止,SARS-CoV-2感染仍在传播,对公共卫生构成了重大威胁,目前正在采取多项控制措施,以促进其传播。新药的研究和开发除了需要一个缓慢而昂贵的过程外,还需要大量的资金。因此,人们提出了新的技术来简化这一过程。药物的重新定位或重新利用是一种很有吸引力的策略,为引入新药提供了一种很有前途的方法。目前,市场上已经有许多重复使用的药物,并正在实践中。本综述发现,抗病毒药物恩曲他滨和替诺福韦在临床前研究中显示出潜在的治疗疗效。因此,在硅分析中被认为是预测药物有效性的潜在工具,主要是作为一种有效的方法,以鼓励一个互补的体外和体内抗病毒评估。
关键词: Covid-19、SARS-CoV-2、药物、再利用、抗病毒药物、治疗。
Current Medicinal Chemistry
Title:Potential Repurposing of Drugs with Anti-SARS-CoV-2 Activity in Preclinical Trials: A Systematic Review
Volume: 28 Issue: 22
关键词: Covid-19、SARS-CoV-2、药物、再利用、抗病毒药物、治疗。
摘要: COVID-19 is an emerging outbreak similar to previous pandemics caused by Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS). Till date, SARS-CoV-2 infection is still spreading, representing a major threat to public health, where several control measures are being practiced in order to culminate its spread. The research and development of new drugs require a lot of funding in addition to being a slow and costly process. As a result, new techniques have been proposed to streamline this process. The repositioning or repurposing of drugs represents an attractive strategy, presenting a promising way to introduce new drugs. Currently, numerous reused drugs are already available in the market and are in practice. In this review, it was observed that the antiviral drugs Entricitabine and Tenofovir display potential therapeutic efficacy in preclinical studies. Therefore, in silico analyses were considered a potential tool for predicting the effectiveness of drugs, mainly as an effective approach to encourage a complementary in vitro and in vivo antiviral evaluation.
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Cite this article as:
Potential Repurposing of Drugs with Anti-SARS-CoV-2 Activity in Preclinical Trials: A Systematic Review, Current Medicinal Chemistry 2021; 28 (22) . https://dx.doi.org/10.2174/0929867327666201005113204
DOI https://dx.doi.org/10.2174/0929867327666201005113204 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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