Title:1, 2, 4-triazoles Clubbed Pyrimidine Compounds with Synthesis, Antimicrobial, Antituberculosis, Antimalarial, and Anti-protozoal Studies
Volume: 18
Issue: 8
Author(s): Navin B. Patel*, Hetal I. Soni*, Rahul B. Parmar, Manuel J. Chan-Bacab and Gildardo Rivera
Affiliation:
- Organic Research Laboratory, Department of Chemistry, Veer Narmad South Gujarat University, Udhana-Magdalla Road, Surat-395 007, Gujarat,India
- C. B. Patel Computer & J. N. M. Patel Science College, Surat-395 017, Gujarat,India
Keywords:
Triazole, pyrimidines, antimicrobial, anti-tuberculosis, antimalarial, anti-protozoal.
Abstract: Triazoles are famous as an antifungal agent. Itraconazole and fluconazole are the best
examples of antifungal drugs available in the market, which consist of an active triazole moiety.
Pyrimidines are also bioactive molecules which shows multiple bioactivity. It’s an effort to synthesize
pyrimidine clubbed triazole to enhance bioactivity. To synthesize new active pyrimidine
clubbed triazole biomolecule and to evaluate these new products for better drug potential as antimicrobial,
antituberculosis, antimalarial, and anti-protozoal, N-[4-(substituted phenyl)-6-
(substituted aryl) pyrimidine-2-yl]-2-[(4H-1,2,4-triazol-4-yl)amino]acetamide(3A-J) were synthesized
by different method such as cyclization, condensation, purification and crystallization. The
newly synthesized compounds were characterized by IR, 1H NMR, 13C NMR and mass spectral
analysis and screened for antibacterial, antifungal, anti-tuberculosis, antimalarial, and antiprotozoal
activities. These compounds satisfied the bioactive response and simple way for the synthesis.
