Title:Phytochemicals for Drug Discovery in Alzheimer’s Disease: In Silico Advances
Volume: 27
Issue: 25
Author(s): Smriti Sharma and Vinayak Bhatia*
Affiliation:
- Department of Glaucoma, ICARE Eye Hospital and Postgraduate Institute, U.P., Noida,India
Keywords:
In silico medicine, computational drug design, Alzheimer's disease, phytochemicals, molecular modelling, drug targets.
Abstract: The search for novel drugs that can prevent or control Alzheimer’s disease has attracted a lot of attention
from researchers across the globe. Phytochemicals are increasingly being used to provide scaffolds to design
drugs for AD. In silico techniques have proven to be a game-changer in this drug design and development
process. In this review, the authors have focussed on current advances in the field of in silico medicine, applied
to phytochemicals, to discover novel drugs to prevent or cure AD. After giving a brief context of the etiology
and available drug targets for AD, authors have discussed the latest advances and techniques in computational
drug design of AD from phytochemicals. Some of the prototypical studies in this area are discussed in detail. In
silico phytochemical analysis is a tool of choice for researchers all across the globe and helps integrate chemical
biology with drug design.
