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Current Pharmaceutical Design

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ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

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General Research Article

A Glassy Carbon Electrode for the Determination of Linagliptin, an Antidiabetic Drug in Pure Form, Tablets and Some Biological Fluids by Adsorptive Stripping Voltammetry

Author(s): Ahmed A. Gahlan, Ahmed M. Haredy*, Sayed M. Derayea, Mahmoud A. Omar and Gamal A. Saleh

Volume 27, Issue 20, 2021

Published on: 25 September, 2020

Page: [2415 - 2424] Pages: 10

DOI: 10.2174/1381612826666200925123245

Price: $65

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Abstract

Aim: The present work provides a fast, simple, accurate, and inexpensive analytical method for the determination of Linagliptin (anti-diabetic drug).

Methods: The analysis was performed using a square wave adsorptive anodic stripping voltammetric technique (SWAASV) and glassy carbon electrode (GCE) as a working electrode. The experimental and instrumental parameters were studied and discussed to ensure the validity of the method.

Results: The method has a very good linearity (R2 = 0.9984), wide concentration range (0.189 - 2.268 μg mL-1), low detection limit of 0.052 μg mL-1 and low quantitation limit of 0.172 μg mL-1.

Conclusion: Linagliptin was identified successfully using the proposed method in pharmaceutical formulations, spiked human urine and plasma with 99.67, 91.96, and 92.78% recovery, respectively, and the results obtained were compared with other reported methods.

Keywords: Linagliptin, glassy carbon electrode, Square wave voltammetry, Pharmaceutical, pure form, biological fluids.

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