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Abstract
Objective: To determine the circulatory miRNA expression levels in patients with Hashimoto thyroiditis (HT) at the time of diagnosis and follow-up period compared with healthy controls.
Methods: We collected blood samples from 34 patients with HT (4 males and 30 females) at the time of first diagnosis (Group P) and euthyroid period (Group E). Thirty-three healthy controls (Group H) blood samples were also included in the study. Expression levels of five different circulating miRNAs (miR-22, miR-141, miR-155, miR-375, miR-451) were evaluated using real-time polymerase chain reaction.
Results: There was a significant difference in miR-375 levels between the groups P and H. Also, for miR-451, there was a significant difference between the P and E groups. Finally, there was a moderate positive correlation between thyroid-stimulating hormone values and miR-22 expression levels for the P group.
Conclusion: miRNAs have important roles at all stages of the diseases. More studies must be performed in all thyroid diseases and autoimmune diseases, including HT.
Keywords: Circulatory miRNA, Hashimoto thyroiditis, miR-451, miR-375, miR-22, autoimmune condition.
[http://dx.doi.org/10.1210/jcem.87.2.8182] [PMID: 11836274]
[http://dx.doi.org/10.1556/oh.2007.28032] [PMID: 17430791]
[http://dx.doi.org/10.1016/S0889-8529(05)70136-5] [PMID: 10874534]
[http://dx.doi.org/10.1016/j.molmed.2006.01.004] [PMID: 16473043]
[http://dx.doi.org/10.1111/j.1365-2567.2009.03092.x] [PMID: 19538248]
[http://dx.doi.org/10.1038/nrclinonc.2011.76] [PMID: 21647195]
[http://dx.doi.org/10.1007/s11033-011-1441-7] [PMID: 22231906]
[http://dx.doi.org/10.1016/j.trsl.2012.04.002] [PMID: 22683424]
[http://dx.doi.org/10.1111/cen.12432] [PMID: 24533739]
[http://dx.doi.org/10.1016/j.autrev.2015.07.005] [PMID: 26164649]
[http://dx.doi.org/10.1371/journal.pone.0025832] [PMID: 22003408]
[http://dx.doi.org/10.1089/thy.2012.0277] [PMID: 22957494]
[http://dx.doi.org/10.1146/annurev.immunol.19.1.683] [PMID: 11244051]
[http://dx.doi.org/10.1038/ni1540] [PMID: 17994023]
[http://dx.doi.org/10.1182/blood-2005-01-0191] [PMID: 15701712]
[http://dx.doi.org/10.3389/fendo.2012.00102] [PMID: 22969748]
[http://dx.doi.org/10.1038/onc.2010.169] [PMID: 20498632]
[http://dx.doi.org/10.1136/gutjnl-2012-304213] [PMID: 24000293]
[http://dx.doi.org/10.1177/0961203307084158] [PMID: 18042587]
[http://dx.doi.org/10.1038/mi.2012.16] [PMID: 22453679]
[http://dx.doi.org/10.1210/jc.2011-2982] [PMID: 22456620]
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