Title:Pharmaceutical Aspects of Green Synthesized Silver Nanoparticles: A Boon to Cancer Treatment
Volume: 21
Issue: 12
Author(s): Vijay Mishra*, Pallavi Nayak, Manvendra Singh, Murtaza M. Tambuwala, Alaa A. Aljabali, Dinesh K. Chellappan and Kamal Dua
Affiliation:
- School of Pharmaceutical Sciences, Lovely Professional University, Phagwara (Punjab), 144411,India
Keywords:
Nanotechnology, silver nanoparticles, green synthesis, biomedical applications, toxicity, anticancer effect.
Abstract:
Background: Silver nanoparticles (AgNPs) are among the most investigated nanostructures in recent
years, which exhibit more challenging and promising qualities in different biomedical applications. The AgNPs
synthesized by the green approach provide potential healthcare benefits over chemical approaches, including
improvement of tissue restoration, drug delivery, diagnosis, being environmentally friendly, and a boon to cancer
treatment.
Objective: In the current scenario, the development of safe and effective drug delivery systems is the utmost
concern of formulation development scientists as well as clinicians.
Methods: Google, Web of Science, and PubMed portals have been searched for potentially relevant literature to
get the latest developments and updated information related to different aspects of green synthesized AgNPs
along with their biomedical applications, especially in the treatment of different types of cancers.
Results: The present review highlights the latest published research regarding the different green approaches for
the synthesis of AgNPs, their characterization techniques as well as various biomedical applications, particularly
in cancer treatment. In this context, environment-friendly AgNPs are proving themselves as better candidates in
terms of size, drug loading and release efficiency, targeting efficiency, minimal drug-associated side effects,
pharmacokinetic profiling, and biocompatibility issues.
Conclusion: With continuous efforts by multidisciplinary team approaches, nanotechnology-based AgNPs will
shed new light on diagnostics and therapeutics in various disease treatments. However, the toxicity issues of
AgNPs need greater attention as unanticipated toxic effects must be ruled out for their diversified applications.