Title:The Effects of P75NTR on Learning Memory Mediated by Hippocampal Apoptosis and Synaptic Plasticity
Volume: 27
Issue: 4
Author(s): Jun-Jie Tang, Shuang Feng, Xing-Dong Chen, Hua Huang, Min Mao, Hai-Yan Wang, Sen Li, Xiu-Min Lu*Yong-Tang Wang*
Affiliation:
- College of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054,China
- State Key Laboratory of Trauma, Burns and Combined Injury, Daping Hospital, Army Medical University, Chongqing 400042,China
Keywords:
Nervous system diseases, learning and memory, hippocampus, apoptosis, synaptic plasticity, P75NTR signaling.
Abstract: Neurological diseases bring great mental and physical torture to the patients, and have long-term and
sustained negative effects on families and society. The attention to neurological diseases is increasing, and the
improvement of the material level is accompanied by an increase in the demand for mental level. The p75 neurotrophin
receptor (p75NTR) is a low-affinity neurotrophin receptor and involved in diverse and pleiotropic effects
in the developmental and adult central nervous system (CNS). Since neurological diseases are usually accompanied
by the regression of memory, the pathogenesis of p75NTR also activates and inhibits other signaling
pathways, which has a serious impact on the learning and memory of patients. The results of studies shown
that p75NTR is associated with LTP/LTD-induced synaptic enhancement and inhibition, suggest that p75NTR
may be involved in the progression of synaptic plasticity. And its proapoptotic effect is associated with activation
of proBDNF and inhibition of proNGF, and TrkA/p75NTR imbalance leads to pro-survival or proapoptotic
phenomena. It can be inferred that p75NTR mediates apoptosis in the hippocampus and amygdale, which may
affect learning and memory behavior. This article mainly discusses the relationship between p75NTR and learning
memory and associated mechanisms, which may provide some new ideas for the treatment of neurological
diseases.
