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Review Article

用现有药物治疗阿尔茨海默病:绕过障碍的有希望的策略

卷 28, 期 12, 2021

发表于: 31 August, 2020

页: [2305 - 2327] 页: 23

弟呕挨: 10.2174/0929867327666200831140745

价格: $65

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摘要

开发治疗阿尔茨海默病的有效药物的需求一直在稳步增长，这是药物发现的一个重大挑战。在这种情况下，药物再利用，即为已批准或正在研究的化合物识别新的治疗适应症，可以被视为获得新药的一种有吸引力的尝试，可以减少研发项目通常所需的时间和经济负担。在过去的几年里，一些类别的药物证明对神经退行性疾病有很好的疗效，其中一些已经开始了初步的临床试验。这篇综述的目的是阐述一些最新的治疗阿尔茨海默病药物的例子，不仅考虑到现有药物的新用途的发现，而且考虑到疾病发病机制的新假设，可以促进以前未考虑的治疗方案。此外，还将介绍一些为获得多功能化合物而对现有药物进行结构修饰的例子。

关键词: 药物再利用，药物重组，多靶点药物，阿尔茨海默病，抗生素，螯合剂，抗糖尿病药

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