Title:Nanotechnology-based Drug Delivery Systems as Potential for Skin Application: A Review
Volume: 28
Issue: 16
关键词:
液晶、立方体、脂质体、纳米乳剂、环糊精、树枝状聚合物、皮肤应用。
摘要: Administration of substances through the skin represents a promising alternative, in
relation to other drug administration routes, due to its large body surface area, in order to offer
ideal and multiple sites for drug administration. In addition, the administration of drugs
through the skin avoids the first-pass metabolism, allowing an increase in the bioavailability
of drugs, as well as reducing their side effects. However, the stratum corneum (SC) comprises
the main barrier of protection against external agents, mainly due to its structure, composition
and physicochemical properties, becoming the main limitation for the administration of substances
through the skin. In view of the above, pharmaceutical technology has allowed the
development of multiple drug delivery systems (DDS), which include liquid crystals (LC),
cubosomes, liposomes, polymeric nanoparticles (PNP), nanoemulsions (NE), as well as cyclodextrins
(CD) and dendrimers (DND). It appears that the DDS circumvents the problems
of drug absorption through the SC layer of the skin, ensuring the release of the drug, as well
as optimizing the therapeutic effect locally. This review aims to highlight the DDS that include
LC, cubosomes, lipid systems, PNP, as well as CD and DND, to optimize topical skin
therapies.
