Rhodium-Catalyzed Decarboxylative Michael Reaction of Coumarin-3- Carboxylic Acids with N-heterocycles Triggered by C-H Bond Functionalization

Title:Rhodium-Catalyzed Decarboxylative Michael Reaction of Coumarin-3- Carboxylic Acids with N-heterocycles Triggered by C-H Bond Functionalization

Volume: 18 Issue: 11

Author(s): Shanshan Xun and Lina Jia*

Affiliation:

• College of Chemistry and Chemical Engineering, Qiqihar University, Qiqihar 161006,China

Keywords: C-H activation, rhodium, coumarin, decarboxylative addition, dihydrocoumarin, N-heterocycle.

Abstract: Rhodium-catalyzed hydrocarbon bond activation of N-heterocycles and decarboxylative Michael addition with coumarin-3-carboxylic acids has been well achieved. Various N-heterocycles substituted 3,4-dihydrocoumarin could be easily provided with excellent chemo- and regioselectivity in good to excellent yields. A class of functional groups on N-heterocycles and coumarin-3-carboxylic acids is compatible with this process. A stoichiometric amount of Zn(OAc)2 is necessary for the high yield of products.

Cite this article as:

Xun Shanshan and Jia Lina *, Rhodium-Catalyzed Decarboxylative Michael Reaction of Coumarin-3- Carboxylic Acids with N-heterocycles Triggered by C-H Bond Functionalization, Letters in Organic Chemistry 2021; 18 (11) . https://dx.doi.org/10.2174/1570178617999200818171024