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Review Article

药物再利用:依达拉奉靶向药物治疗创伤性脑损伤的前景

卷 28, 期 12, 2021

发表于: 12 August, 2020

页: [2369 - 2391] 页: 23

弟呕挨: 10.2174/0929867327666200812221022

价格: $65

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摘要

依达拉奉是一种有效的自由基清除剂，在市场上已有30多年的历史。它最初是在日本开发的，用于治疗中风，自2001年以来一直在日本使用。除抗氧化作用外，依达拉奉在促炎症反应、一氧化氮生成和凋亡细胞死亡方面表现出有益作用。有趣的是，依达拉奉在除中风以外的几种疾病动物模型中显示了神经保护作用。特别是，研究发现依达拉奉在早期阶段可以有效阻止肌萎缩侧索硬化症(ALS)的进展。因此，依达拉奉在III期临床试验中获得成功后，已被FDA批准作为ALS患者的治疗药物。考虑到依达拉奉对神经系统疾病的疗效和安全性，依达拉奉是一种值得关注的药物，可用于创伤性脑损伤(TBI)的治疗。药物再利用是一种新的药物开发方法，用于确定药物的用途，而不是其原来的适应症。本文综述依达拉奉的生化特性及其对几种神经功能障碍的作用，以期其在创伤性脑损伤治疗中得到应用。

关键词: 创伤性脑损伤(TBI)，药物再利用，依达拉奉，肌萎缩侧索硬化症，中风，神经障碍

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