Title:A Mini-Review on Nano Technology in the Tumour Targeting Strategies: Drug Delivery to Cancer Cells
Volume: 20
Issue: 17
Author(s): Loveleen Kaur, Harvinder S. Sohal*, Manvinder Kaur, Dharambeer S. Malhi and Sonali Garg
Affiliation:
- Medicinal and Natural Product Laboratory, Department of Chemistry, Chandigarh University, Gharuan-140413, Mohali, Punjab,India
Keywords:
Nanoparticles, liposomes, carbon dots, micelles, drug delivery systems, tumour targeting strategies.
Abstract:
Background: Recently, the application of cancer nanotechnology-based drug delivery to cancer cells
has arisen as an important method to resolve multiple molecular, biophysical, and biochemical obstacles, which
the body is preparing to resist against the productive implementation of chemotherapeutic medications. Drug
delivery technologies focused on nanoparticles, which have resolved some of the drawbacks of conventional
chemotherapy as, decreased drug viscosity, chemo-resistance, precise malignity, limited medicative measures
with low oral bioactivity. Due to their adjustable size and surface properties, the half-life period of a drug can be
increased in the bloodstream.
Objective: The aim of the current study is to collect and document the data available on the drug delivery system
for anticancer drugs. The present study includes some of the drug carriers like liposomes, carbon dots, micelles,
carbon nanotubes, magnetic nanoparticles, etc.
Methods: To write this review, an exhaustive literature survey was carried out using relevant work published in
various SCI, Scopus, and non-SCI indexed journals. The different search engines used to download the research/
review papers are Google search, PubMed, Science Direct, Google Scholar, Scientific Information Database
and Research Gate, etc.
Results: Nanotechnology offers better pharmacokinetics, reduces the systematic toxicities related to the chemotherapies
and a better route of drug administration. In the analysis, we critically highlight recent studies on
carcinoma-fighting nanotechnology.
Conclusion: In the present study, different kinds of nano-based drug delivery systems have been discussed
along with their characteristic features, the encapsulation of anticancer agents into different types of nanometresized
vehicles and their general mechanism.
